Assignment of the β-N-acetylhexosaminidase gene (HEXB) to porcine chromosome SSC2q21→q22 by fluorescence in situ hybridization and by analysis of somatic cell and radiation hybrid panels
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Assignment of the CALC-A/alpha-CGRP gene (CALCA) to porcine chromosome SSC2p13-->p11 by fluorescence in situ hybridization and by analysis of somatic cell and radiation hybrid panels.
Calcitonin and ·-CGRP are products of the alternatively spliced gene CALCA. Calcitonin (CALC) mRNA is predominantly found in thyrodial C cells and mRNA encoding the neuropeptide calcitonin gene-related peptide (CGRP) in neural tissues (Amara et al., 1982, Rosenfeld et al., 1983). In vivo, calcitonin reduces serum calcium and acts as an antagonist to the parathyroid hormone. The human CALC-A/·-C...
متن کاملAssignment of the methylmalonyl-CoA mutase gene (MUT) to porcine chromosome 7q13-->q14 by in situ hybridization and analysis of radiation hybrid panels.
Methylmalonyl-CoA mutase (MCM) is a nuclear encoded mitochondrial matrix enzyme which catalyses the isomerisation between methylmalonyl-CoA and succinyl-CoA. Inborn genetic defects in the MUT gene encoding human MCM give rise to a serious disorder of propionic acid and methylmalonic acid metabolism termed mut methylmalonic aciduria (Crane et al., 1994). The clinical manifestation of the disease...
متن کاملAssignment of the PHACTR1 gene to bovine chromosome 23q24 by fluorescence in situ hybridization and radiation hybrid mapping.
The phosphatase and actin regulator (PHACTR) proteins represent a family of protein phosphatase 1 (PP1) and actin regulatory proteins. PP1 is a multifunctional enzyme with diverse roles in the nervous system, including regulation of synaptic activity and dendritic morphology. In rat the Phactr1 gene was cloned for the first time as the prototypical member of this family (Allen et al., 2004). By...
متن کاملAssignment of the canine myosin Va gene (MYO5A) to chromosome 30q14 by fluorescence in situ hybridization and radiation hybrid mapping.
Myosin Va belongs to the unconventional myosin family that has been identified in many non-muscle tissues of vertebrates and invertebrates. All known myosins bind actin and produce mechanical force through ATP hydrolysis. Myosin Va is only expressed in melanocytes and in cells of the neuronal system (Mercer et al., 1991). In melanocytes it is part of the melanosome transport complex (Wu et al.,...
متن کاملRetrospective assessment of radiation dose by Fluorescence In Situ Hybridization and evaluation of stable chromosomal aberrations
Estimation of absorbed dose for radiation workers or person involved in different radiological accident is the aim of biodosimetry. Cytogenetic methods are the most current and applicable biodosimetry tools. In chronic or protracted exposure, fluorescence in situ hybridization (FISH), stable chromosomal aberration is used for estimation of absorbed dose. For precise estimation of absorbed dose,...
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ژورنال
عنوان ژورنال: Cytogenetic and Genome Research
سال: 2003
ISSN: 1424-8581,1424-859X
DOI: 10.1159/000074176